HU-331Description
HU-331isacannABInoid-basedquinonewithpotentialanticanceractivity. Ithasanti-topoIIaactivityasacatalyticinhibitorratherthaapoison(suchasetoposide).
ChemicalName:3-hyroxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-2,5-cyclohexADIene-1,4-dione
MolecularFormula:C21H28O3
MolecularWeight:328.5
HU-331actstoinhibittheATPaseactivityoftheenzymeandhasbeenshowntobeeffectiveinkillingtumorcells. Thedrugmayalsoinfluenceredoxassociatedaction. RecentworkhasshownthatHU-331blockcatalyticactionoftopoisomeraseIIandtheactionisspecificforhumantopoIIaanddoesnotactonDNAgyrasefromE.colioronhumantopoI. Theinhibitoryactionisredoxdependent. TopoGENprovidesthisreagentasacontrolinhibitoroftopoisomeraseIIaanditisnotrecommendedasacontrolforinterfacialpoisoning. HU-331issomewhataqueoussoluble(upto0.5mg/mlin50%ethanolinPBSbuffer). Thedrugispre-testedandshowntoinhibitrelaxation,decatenationandDNAcleavageactivityofhumanDNAtopoisomeraseIIa.
VialContents:
TG4200contains25ulof10mMsolutionofHU-331in100%DMSO(correspondingto3.28mg/ml).